News & Views | Published:

Multiple sclerosis

One protein, two healing properties

Nature volume 477, pages 287288 (15 September 2011) | Download Citation

Multiple sclerosis is linked to rogue immune cells that attack mature neurons. Remarkably, immature neurons secrete a protein called LIF, which not only inhibits this attack, but also promotes repair of the damaged nerves.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Nature 422, 688–694 (2003).

  2. 2.

    et al. Immunity 35, 1–12 (2011).

  3. 3.

    Stem Cells 21, 5–14 (2003).

  4. 4.

    et al. Nature Immunol. 6, 1123–1132 (2005).

  5. 5.

    et al. Cell Cycle 8, 1444–1450 (2009).

  6. 6.

    et al. Mol. Pharmaceut. 8, 143–152 (2011).

  7. 7.

    et al. Mol. Ther. 18, 684–691 (2010).

  8. 8.

    et al. Brain 133, 2232–2247 (2010).

Download references

Author information

Affiliations

  1. Su M. Metcalfe is in the Brain Repair Centre, Department of Neurology, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0PY, UK.

    • Su M. Metcalfe

Authors

  1. Search for Su M. Metcalfe in:

Corresponding author

Correspondence to Su M. Metcalfe.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/477287a

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing