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Let sleeping DNA lie

In hereditary breast and ovarian cancers caused by absence of the BRCA1 protein, genomic instability may ensue from the 'awakening' of repetitive DNA sequences in structurally condensed chromosomal regions. See Article p.179

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Figure 1: BRCA1 loss, satellite-DNA transcription and genomic instability.


  1. Zhu, Q. et al. Nature 477, 179–184 (2011).

    Article  ADS  CAS  Google Scholar 

  2. Venkitaraman, A. R. Annu. Rev. Pathol. 4, 461–487 (2009).

    Article  CAS  Google Scholar 

  3. Maison, C. & Almouzni, G. Nature Rev. Mol. Cell Biol. 5, 296–304 (2004).

    Article  CAS  Google Scholar 

  4. Higashi, M., Inoue, S. & Ito, T. Exp. Cell Res. 316, 2707–2712 (2010).

    Article  CAS  Google Scholar 

  5. Van Attikum, H. & Gasser, S. Trends Cell Biol. 19, 207–217 (2009).

    Article  CAS  Google Scholar 

  6. Wang, H. et al. Nature 431, 873–878 (2004).

    Article  ADS  CAS  Google Scholar 

  7. Zhang, F. et al. Curr. Biol. 19, 524–529 (2009).

    Article  CAS  Google Scholar 

  8. Sy, S. M., Huen, M. S. & Chen, J. Proc. Natl Acad. Sci. USA 106, 7155–7160 (2009).

    Article  ADS  CAS  Google Scholar 

  9. Reid, L. J. et al. Proc. Natl Acad. Sci. USA 105, 20876–20881 (2008).

    Article  ADS  CAS  Google Scholar 

  10. Ting, D. T. et al. Science 331, 593–596 (2011).

    Article  ADS  CAS  Google Scholar 

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Correspondence to Ashok R. Venkitaraman.

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Venkitaraman, A. Let sleeping DNA lie. Nature 477, 169–170 (2011).

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