Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Ageing

Blood ties

The brain's ability to generate new neurons declines with age. This reduction is mediated by increased levels of an inflammatory factor in the blood of ageing mice and is associated with deficits in learning and memory. See Letter p.90

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Lazarini, F. & Lledo, P. M. Trends Neurosci. 34, 20–30 (2011).

    CAS  Article  Google Scholar 

  2. Aimone, J. B., Deng, W. & Gage, F. H. Trends Cogn. Sci. 14, 325–337 (2010).

    Article  Google Scholar 

  3. Villeda, S. A. et al. Nature 477, 90–94 (2011).

    ADS  CAS  Article  Google Scholar 

  4. Vallières, L., Campbell, I. L., Gage, F. H. & Sawchenko, P. E. J. Neurosci. 22, 486–492 (2002).

    Article  Google Scholar 

  5. Kronenberg, G. et al. Neurobiol. Aging 27, 1505–1513 (2006).

    Article  Google Scholar 

  6. Ransohoff, R. M. Immunity 31, 711–721 (2009).

    CAS  Article  Google Scholar 

  7. Dambly-Chaudière, C., Cubedo, N. & Ghysen, A. BMC Dev. Biol. 7, 23 (2007).

    Article  Google Scholar 

  8. Wang, Y. et al. Neuron 69, 61–76 (2011).

    CAS  Article  Google Scholar 

  9. Li, M. & Ransohoff, R. M. Prog. Neurobiol. 84, 116–131 (2008).

    CAS  Article  Google Scholar 

  10. He, J. et al. Nature 385, 645–649 (1997).

    ADS  CAS  Article  Google Scholar 

  11. Choi, S. H. et al. Neuron 59, 568–580 (2008).

    CAS  Article  Google Scholar 

  12. Krathwohl, M. D. & Kaiser, J. L. Stem Cells 22, 109–118 (2004).

    CAS  Article  Google Scholar 

  13. Wainwright, D. A. et al. ASN Neuro 1, e00024 (2009).

    Article  Google Scholar 

  14. Derecki, N. C. et al. J. Exp. Med. 207, 1067–1080 (2010).

    CAS  Article  Google Scholar 

  15. Stevenson, N. J. et al. J. Leukoc. Biol. 85, 289–297 (2009).

    CAS  Article  Google Scholar 

  16. Huang, G. J. et al. PLoS Biol. 8, e1000561 (2010).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Richard M. Ransohoff.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ransohoff, R. Blood ties. Nature 477, 41–42 (2011). https://doi.org/10.1038/477041a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/477041a

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing