Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Stem cells

Orphan receptors find a home

The protein Lgr5 has been valuable as the undisputed marker of intestinal and other stem cells. It emerges that Lgr5 and its relatives also have essential signalling roles of relevance to health and disease. See Article p.293

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Cooperative signalling within stem cells.


  1. Carmon, K. S., Gong, X., Lin, Q., Thomas, A. & Liu, Q. Proc. Natl Acad. Sci. USA 108, 11452–11457 (2011).

    Article  ADS  CAS  Google Scholar 

  2. de Lau, W. et al. Nature 476, 293–297 (2011).

    Article  ADS  CAS  Google Scholar 

  3. Klaus, A. & Birchmeier, W. Nature Rev. Cancer 8, 387–398 (2008).

    Article  CAS  Google Scholar 

  4. Morita, H. et al. Mol. Cell. Biol. 24, 9736–9743 (2004).

    Article  CAS  Google Scholar 

  5. Snippert, H. J. et al. Science 327, 1385–1389 (2010).

    Article  ADS  CAS  Google Scholar 

  6. Barker, N. et al. Nature 449, 1003–1007 (2007).

    Article  ADS  CAS  Google Scholar 

  7. Sato, T. et al. Nature 459, 262–265 (2009).

    Article  ADS  CAS  Google Scholar 

  8. Blaydon, D. C. et al. Nature Genet. 38, 1245–1247 (2006).

    Article  CAS  Google Scholar 

  9. Binnerts, M. E. et al. Proc. Natl Acad. Sci. USA 104, 14700–14705 (2007).

    Article  ADS  CAS  Google Scholar 

  10. Parma, P. et al. Nature Genet. 38, 1304–1309 (2006).

    Article  CAS  Google Scholar 

  11. Kazanskaya, O. et al. Development 135, 3655–3664 (2008).

    Article  CAS  Google Scholar 

  12. Ben-Porath, I. et al. Nature Genet. 40, 499–507 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Walter Birchmeier.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Birchmeier, W. Orphan receptors find a home. Nature 476, 287–288 (2011).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing