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Stem cells

Orphan receptors find a home

The protein Lgr5 has been valuable as the undisputed marker of intestinal and other stem cells. It emerges that Lgr5 and its relatives also have essential signalling roles of relevance to health and disease. See Article p.293

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Figure 1: Cooperative signalling within stem cells.

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Correspondence to Walter Birchmeier.

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Birchmeier, W. Orphan receptors find a home. Nature 476, 287–288 (2011). https://doi.org/10.1038/476287a

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