Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Regenerative medicine

Bespoke cells for the human brain

Human skin cells have been directly converted into neurons, an achievement that could lead to the cell-based treatment of neurodegenerative disorders. But the road ahead remains long and tortuous. See Letters p.220, p.224 & p.228

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout


  1. Pang, Z. P. et al. Nature 476, 220–223 (2011).

    Article  ADS  CAS  Google Scholar 

  2. Caiazzo, M. et al. Nature 476, 224–227 (2011).

    Article  ADS  CAS  Google Scholar 

  3. Yoo, A. S. et al. Nature 476, 228–231 (2011).

    Article  ADS  CAS  Google Scholar 

  4. Gore, A. et al. Nature 471, 63–67 (2011).

    Article  ADS  CAS  Google Scholar 

  5. Vierbuchen, T. et al. Nature 463, 1035–1041 (2010).

    Article  ADS  CAS  Google Scholar 

  6. Pfisterer, U. et al. Proc. Natl Acad. Sci. USA 108, 10343–10348 (2011).

    Article  ADS  CAS  Google Scholar 

  7. Siegmund, K. D. et al. PLoS ONE 2, e895 (2007).

    Article  ADS  Google Scholar 

  8. Covic, M., Karaca, E. & Lie, D. C. Heredity 105, 122–134 (2010).

    Article  CAS  Google Scholar 

  9. Yoo, A. S., Staahl, B. T., Chen, L. & Crabtree, G. R. Nature 460, 642–646 (2009).

    Article  ADS  CAS  Google Scholar 

  10. Miller, C. A. & Sweatt, J. D. Neuron 53, 857–869 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Michael Sendtner.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sendtner, M. Bespoke cells for the human brain. Nature 476, 158–159 (2011).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research