Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Magnesium in a signalling role

Magnesium binds to enzymes and nucleic acids and is essential for their activity. It emerges that this ion can also function as a signalling molecule with a crucial role in the immune system. See Article p.471

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: MAGT1 in T-cell activation.


  1. Casanova, J. L. & Abel, L. Science 317, 617–619 (2007).

    ADS  CAS  Article  Google Scholar 

  2. Li, F. et al. Nature 475, 471–476 (2011).

    CAS  Article  Google Scholar 

  3. Smith-Garvin, J. E., Koretzky, G. A. & Jordan, M. S. Annu. Rev. Immunol. 27, 591–619 (2009).

    CAS  Article  Google Scholar 

  4. Zhou, H. & Clapham, D. E. Proc. Natl Acad. Sci. USA 106, 15750–15755 (2009).

    ADS  CAS  Article  Google Scholar 

  5. Rijkers, G. T. & Griffioen, A. W. Biochem. J. 289, 373–377 (1993).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to André Veillette.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Wu, N., Veillette, A. Magnesium in a signalling role. Nature 475, 462–463 (2011).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing