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Cardiovascular disease

Several small shocks beat one big one

Life-threatening abnormalities in the electrical rhythm of the heart are usually treated with the application of a large electric shock. An approach involving a significantly smaller shock energy may be equally effective. See Letter p.235

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Figure 1: Subtle defibrillation.

References

  1. Gray, R. A., Pertsov, A. M. & Jalife, J. Nature 392, 75–78 (1998).

    Article  ADS  CAS  Google Scholar 

  2. Dosdall, D. J. & Ideker, R. E. Heart Rhythm 4, S51–S56 (2007).

    Article  Google Scholar 

  3. Luther, S. et al. Nature 475, 235–239 (2011).

    Article  ADS  CAS  Google Scholar 

  4. Wikswo, J. P., Lin, S. F. & Abbas, R. A. Biophys. J. 69, 2195–2210 (1995).

    Article  ADS  CAS  Google Scholar 

  5. Pak, H.-N. et al. Am. J. Physiol. Heart Circ. Physiol. 285, H2704–H2711 (2003).

    Article  CAS  Google Scholar 

  6. Hosfeld, V. D. et al. J. Biol. Phys. 33, 145–153 (2007).

    Article  Google Scholar 

  7. Allessie, M. et al. Circulation 84, 1689–1697 (1991).

    Article  CAS  Google Scholar 

  8. Davidenko, J. M. et al. Circ. Res. 77, 1166–1179 (1995).

    Article  CAS  Google Scholar 

  9. Ditto, W. L. et al. Int. J. Bifurc. Chaos 10, 593–601 (2000).

    Google Scholar 

  10. Kok, L. C. & Ellenbogen, K. A. Cardiol. Clin. 22, 71–86 (2004).

    Article  Google Scholar 

  11. Fishler, M. G. J. Cardiovasc. Electrophysiol. 9, 384–394 (1998).

    Article  CAS  Google Scholar 

  12. Sobie, E. A., Susil, R. C. & Tung, L. Biophys. J. 73, 1410–1423 (1997).

    Article  ADS  CAS  Google Scholar 

  13. Trayanova, N. A., Roth, B. J. & Malden, L. J. IEEE Trans. Biomed. Eng. 40, 899–908 (1993).

    Article  CAS  Google Scholar 

  14. Bishop, M. J. et al. IEEE Trans. Biomed. Eng. 57, 2335–2345 (2010).

    Article  Google Scholar 

  15. Maleckar, M. M. et al. Am. J. Physiol. Heart Circ. Physiol. 295, H1626–H1633 (2008).

    Article  CAS  Google Scholar 

  16. Pumir, A. et al. Phys. Rev. Lett. 99, 208101 (2007).

    Article  ADS  CAS  Google Scholar 

  17. Ideker, R. E., Zhou, X. & Knisley, S. B. Pacing Clin. Electrophysiol. 18, 512–525 (1995).

    Article  CAS  Google Scholar 

  18. Cartee, L. A. & Plonsey, R. IEEE Trans. Biomed. Eng. 39, 76–85 (1992).

    Article  CAS  Google Scholar 

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Correspondence to Richard A. Gray or John P. Wikswo.

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Gray, R., Wikswo, J. Several small shocks beat one big one. Nature 475, 181–182 (2011). https://doi.org/10.1038/475181a

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