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Metabolism

Alcohol, DNA and disease

Nature volume 475, pages 45–46 (2011)Cite this article

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Acetaldehyde, a reactive metabolite of ethanol, can damage DNA unless properly processed. A biochemical pathway involved in Fanconi anaemia seems to be essential for protection against such damage. See Article p.53

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Figure 1: Acetaldehyde metabolism and the Fanconi anaemia pathway of DNA repair.

References

  1. http://www.fanconi.org

  2. Langevin, F., Crossan, G. P., Rosado, I. V., Arends, M. J. & Patel, K. J. Nature 475, 53–58 (2011).

    Article  CAS  Google Scholar 

  3. Ridpath, J. R. et al. Cancer Res. 67, 11117–11122 (2007).

    Article  CAS  Google Scholar 

  4. Lorenti Garcia, C. et al. Mutat. Res. 662, 3–9 (2009).

    Article  CAS  Google Scholar 

  5. Marchitti, S. A., Brocker, C., Stagos, D. & Vasiliou, V. Expert Opin. Drug Metab. Toxicol. 4, 697–720 (2008).

    Article  CAS  Google Scholar 

  6. Sulik, K. K., Johnston, M. C. & Webb, M. A. Science 214, 936–938 (1981).

    Article  ADS  CAS  Google Scholar 

  7. Novitskiy, G., Traore, K., Wang, L., Trush, M. A. & Mezey, E. Alcohol Clin. Exp. Res. 30, 1429–1435 (2006).

    Article  CAS  Google Scholar 

  8. Joenje, H. Mutat. Res. 219, 193–208 (1989).

    Article  CAS  Google Scholar 

  9. Brooks, P. J., Enoch, M.-A., Goldman, D., Li, T.-K. & Yokoyama, A. PLoS Med. 6, e50 (2009).

    Article  Google Scholar 

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  1. Hans Joenje is in the Department of Clinical Genetics and the Cancer Center Amsterdam/VUmc Institute for Cancer and Immunology, VU University Medical Center, NL-1081 BT Amsterdam, the Netherlands.,

    Hans Joenje

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  1. Hans Joenje
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Joenje, H. Alcohol, DNA and disease. Nature 475, 45–46 (2011). https://doi.org/10.1038/475045a

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