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Alcohol, DNA and disease

Acetaldehyde, a reactive metabolite of ethanol, can damage DNA unless properly processed. A biochemical pathway involved in Fanconi anaemia seems to be essential for protection against such damage. See Article p.53

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Figure 1: Acetaldehyde metabolism and the Fanconi anaemia pathway of DNA repair.



  2. Langevin, F., Crossan, G. P., Rosado, I. V., Arends, M. J. & Patel, K. J. Nature 475, 53–58 (2011).

    Article  CAS  Google Scholar 

  3. Ridpath, J. R. et al. Cancer Res. 67, 11117–11122 (2007).

    Article  CAS  Google Scholar 

  4. Lorenti Garcia, C. et al. Mutat. Res. 662, 3–9 (2009).

    Article  CAS  Google Scholar 

  5. Marchitti, S. A., Brocker, C., Stagos, D. & Vasiliou, V. Expert Opin. Drug Metab. Toxicol. 4, 697–720 (2008).

    Article  CAS  Google Scholar 

  6. Sulik, K. K., Johnston, M. C. & Webb, M. A. Science 214, 936–938 (1981).

    Article  ADS  CAS  Google Scholar 

  7. Novitskiy, G., Traore, K., Wang, L., Trush, M. A. & Mezey, E. Alcohol Clin. Exp. Res. 30, 1429–1435 (2006).

    Article  CAS  Google Scholar 

  8. Joenje, H. Mutat. Res. 219, 193–208 (1989).

    Article  CAS  Google Scholar 

  9. Brooks, P. J., Enoch, M.-A., Goldman, D., Li, T.-K. & Yokoyama, A. PLoS Med. 6, e50 (2009).

    Article  Google Scholar 

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Correspondence to Hans Joenje.

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Joenje, H. Alcohol, DNA and disease. Nature 475, 45–46 (2011).

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