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DNA repair

Cyclin D1 multitasks

Nature volume 474, pages 171–172 (2011)Cite this article

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Cyclin D1 is one of the drivers of the cell cycle, and its deregulation may promote the development of tumours. Surprisingly, this protein also mediates the repair of damaged DNA, a mechanism that commonly prevents cancer. See Letter p.230

The maintenance of genome integrity is a fundamental biological process. A complex network of proteins detects damaged DNA, signals this detection and repairs the damage, to prevent life-threatening diseases such as cancer1. This machinery is particularly crucial in cells going through the cell-division cycle, a proliferative process that can go awry in various cancers1,2. But the orchestration of the DNA-damage response and the cell cycle is far from understood, despite the key roles of the two processes in cell physiology and pathology. An exciting report by Jirawatnotai and colleagues in this issue3 (page 230) sheds new light on the matter, identifying an unexpected function for the cell-cycle protein cyclin D1 in DNA repair.

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Figure 1: Dual role of cyclin D1.

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Authors and Affiliations

  1. Jiri Bartek and Jiri Lukas are at the Danish Cancer Society, Centre for Genotoxic Stress Research, Copenhagen, Denmark. J.B. is also at the Institute of Molecular and Translational Medicine, Palacky University, Olomouc, Czech Republic.,

    Jiri Bartek & Jiri Lukas

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  1. Jiri Bartek
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  2. Jiri Lukas
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Correspondence to Jiri Bartek or Jiri Lukas.

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Bartek, J., Lukas, J. Cyclin D1 multitasks. Nature 474, 171–172 (2011). https://doi.org/10.1038/474171a

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