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Medicinal chemistry

New lead for pain treatment

The synthesis of conolidine, a scarce, naturally occurring compound, has enabled the first studies of its pharmacological properties to be carried out. Excitingly, conolidine is a painkiller that seems to have an unusual mechanism of action.

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Figure 1: Inspiration for the synthesis of conolidine.


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Correspondence to Sarah E. Reisman.

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Reisman, S. New lead for pain treatment. Nature 473, 458–459 (2011).

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