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The flipside of Notch

Mutations that lead to increased activity of the Notch signalling pathway are well defined in human cancer. New work implicates decreased activity of this pathway in a type of blood cancer. See Letter p.230

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Figure 1: The Notch signalling pathway and blood disorders.


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Correspondence to Demetrios Kalaitzidis or Scott A. Armstrong.

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Kalaitzidis, D., Armstrong, S. The flipside of Notch. Nature 473, 159–160 (2011).

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