Mutations that lead to increased activity of the Notch signalling pathway are well defined in human cancer. New work implicates decreased activity of this pathway in a type of blood cancer. See Letter p.230
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Bone marrow mesenchymal stem cells promote prostate cancer cell stemness via cell–cell contact to activate the Jagged1/Notch1 pathway
Cell & Bioscience Open Access 17 May 2021
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Aster, J. C., Blacklow, S. C. & Pear, W. S. J. Pathol. 223, 263–274 (2011).
Klinakis, A. et al. Nature 473, 230–233 (2011).
Kopan, R. & IIagan, M. X. G. Cell 137, 216–233 (2009).
Koch, U. & Radtke, F. Curr. Top. Dev. Biol. 92, 411–455 (2010).
De Strooper, B., Vassar, R. & Golde, T. Nature Rev. Neurol. 6, 99–107 (2010).
Demehri, S. et al. PLoS Biol. 6, e123 (2008).
Dumortier, A. et al. PLoS One 5, e9258 (2010).
Duncan, A. W. et al. Nature Immunol. 6, 314–322 (2005).
Maillard, I. et al. Cell Stem Cell 2, 356–366 (2008).
Demehri, S., Turkoz, A. & Kopan, R. Cancer Cell 16, 55–66 (2009).
Liu, Z. et al. J. Clin. Invest. 121, 800–808 (2011).
Hanlon, L. et al. Cancer Res. 70, 4280–4286 (2010).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Kalaitzidis, D., Armstrong, S. The flipside of Notch. Nature 473, 159–160 (2011). https://doi.org/10.1038/473159a
Published:
Issue Date:
DOI: https://doi.org/10.1038/473159a