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Biochemistry

Life imitates art

Nature volume 473, pages 35–36 (2011)Cite this article

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The biosynthetic route to a naturally occurring insecticide, spinosyn A, has been established. One of the enzymes involved might catalyse a reaction that, although widely used by chemists, has proved elusive in nature. See Letter p.109

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Figure 1: The biosynthesis of spinosyn A.

References

  1. Huisgen, R. Angew. Chem. Int. Edn 7, 321–328 (1968).

    Article  CAS  Google Scholar 

  2. Kim, H. J., Ruszczycky, M. W., Choi, S., Liu, Y. & Liu, H. Nature 473, 109–112 (2011).

    Article  ADS  CAS  Google Scholar 

  3. Kirst, H. A. J. Antibiot. 63, 101–111 (2010).

    Article  CAS  Google Scholar 

  4. Waldron, C. et al. Chem. Biol. 8, 487–499 (2001).

    Article  CAS  Google Scholar 

  5. Kim, H. J., Pongdee, R., Wu, Q., Hong, L. & Liu, H. J. Am. Chem. Soc. 129, 14582–14584 (2007).

    Article  CAS  Google Scholar 

  6. Mergott, D. J., Frank, S. A. & Roush, W. R. Proc. Natl Acad. Sci. USA 101, 11955–11959 (2004).

    Article  ADS  CAS  Google Scholar 

  7. Auclair, K. et al. J. Am. Chem. Soc. 122, 11519–11520 (2000).

    Article  CAS  Google Scholar 

  8. Kasahara, K. et al. ChemBioChem 11, 1245–1252 (2010).

    Article  CAS  Google Scholar 

  9. Kim, R.-R. et al. J. Am. Chem. Soc. 132, 2983–2990 (2010).

    Article  CAS  Google Scholar 

  10. Watanabe, K., Mie, T., Ichihara, A., Oikawa, H. & Honma, M. J. Biol. Chem. 275, 38393–38401 (2000).

    Article  CAS  Google Scholar 

  11. Ma, S. M. et al. Science 326, 589–592 (2009).

    Article  ADS  CAS  Google Scholar 

  12. Guimarães, C. R. W., Udier-Blagović, M. & Jorgensen, W. L. J. Am. Chem. Soc. 127, 3577–3588 (2005).

    Article  Google Scholar 

  13. Serafimov, J. M., Gillingham, D., Kuster, S. & Hilvert, D. J. Am. Chem. Soc. 130, 7798–7799 (2008).

    Article  CAS  Google Scholar 

Download references

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  1. Wendy L. Kelly is in the School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, USA.,

    Wendy L. Kelly

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  1. Wendy L. Kelly
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Correspondence to Wendy L. Kelly.

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Kelly, W. Life imitates art. Nature 473, 35–36 (2011). https://doi.org/10.1038/473035a

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