Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Immunology

A helping hand against autoimmunity

The TH17 helper cells of the immune system have a dark side: they mediate autoimmune disorders. Two drugs that prevent the differentiation and activity of these cells might be of therapeutic value. See Letters p.486 & p.491

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Effects of digoxin and SR1001 on TH17 cells.

References

  1. Huh, J. R. et al. Nature 472, 486–490 (2011).

    Article  ADS  CAS  Google Scholar 

  2. Solt, L. A. et al. Nature 472, 491–494 (2011).

    Article  ADS  CAS  Google Scholar 

  3. Ivanov, I. I. et al. Cell 126, 1121–1133 (2006).

    Article  CAS  Google Scholar 

  4. Jetten, A. M. Nucl. Recept. Signal. 7, e003 (2009).

    Article  Google Scholar 

  5. Yang, X. O. et al. Immunity 28, 29–39 (2008).

    Article  CAS  Google Scholar 

  6. Kumar, N. et al. Mol. Pharmacol. 77, 228–236 (2010).

    Article  CAS  Google Scholar 

  7. O'Connor, W. Jr, Zenewicz, L. A. & Flavell, R. A. Nature Immunol. 11, 471–476 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Anton M. Jetten.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jetten, A. A helping hand against autoimmunity. Nature 472, 421–422 (2011). https://doi.org/10.1038/472421a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/472421a

This article is cited by

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research