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TRIM5 does double duty

TRIM5 proteins limit retroviral infection by targeting the viral coat. It now seems that these proteins can also serve as pattern-recognition receptors, which initiate cellular innate immune responses. See Letter p.361

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Figure 1: TRIM5 strikes twice.


  1. Wolf, D. & Goff, S. P. Annu. Rev. Genet. 42, 143–163 (2008).

    CAS  Article  Google Scholar 

  2. Stremlau, M. et al. Proc. Natl Acad. Sci. USA 103, 5514–5519 (2006).

    ADS  CAS  Article  Google Scholar 

  3. Pertel, T. et al. Nature 472, 361–365 (2011).

    ADS  CAS  Article  Google Scholar 

  4. Xu, L. et al. Exp. Cell Res. 288, 84–93 (2003).

    CAS  Article  Google Scholar 

  5. Xia, Z.-P. et al. Nature 461, 114–119 (2009).

    ADS  CAS  Article  Google Scholar 

  6. Deng, L. et al. Cell 103, 351–361 (2000).

    CAS  Article  Google Scholar 

  7. Ganser-Pornillos, B. K. et al. Proc. Natl Acad. Sci. USA 108, 534–539 (2011).

    ADS  CAS  Article  Google Scholar 

  8. Langelier, C. R. et al. J. Virol. 82, 11682–11694 (2008).

    CAS  Article  Google Scholar 

  9. Zhao, G. et al. PLoS Pathog. 7, e1002009 (2011).

    CAS  Article  Google Scholar 

  10. Perez-Caballero, D., Hatziioannou, T., Zhang, F., Cowan, S. & Bieniasz, P. D. J. Virol. 79, 15567–15572 (2005).

    CAS  Article  Google Scholar 

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Correspondence to Christopher Aiken.

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Aiken, C., Joyce, S. TRIM5 does double duty. Nature 472, 305–306 (2011).

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