Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Immunology

TRIM5 does double duty

TRIM5 proteins limit retroviral infection by targeting the viral coat. It now seems that these proteins can also serve as pattern-recognition receptors, which initiate cellular innate immune responses. See Letter p.361

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: TRIM5 strikes twice.

References

  1. Wolf, D. & Goff, S. P. Annu. Rev. Genet. 42, 143–163 (2008).

    CAS  Article  Google Scholar 

  2. Stremlau, M. et al. Proc. Natl Acad. Sci. USA 103, 5514–5519 (2006).

    ADS  CAS  Article  Google Scholar 

  3. Pertel, T. et al. Nature 472, 361–365 (2011).

    ADS  CAS  Article  Google Scholar 

  4. Xu, L. et al. Exp. Cell Res. 288, 84–93 (2003).

    CAS  Article  Google Scholar 

  5. Xia, Z.-P. et al. Nature 461, 114–119 (2009).

    ADS  CAS  Article  Google Scholar 

  6. Deng, L. et al. Cell 103, 351–361 (2000).

    CAS  Article  Google Scholar 

  7. Ganser-Pornillos, B. K. et al. Proc. Natl Acad. Sci. USA 108, 534–539 (2011).

    ADS  CAS  Article  Google Scholar 

  8. Langelier, C. R. et al. J. Virol. 82, 11682–11694 (2008).

    CAS  Article  Google Scholar 

  9. Zhao, G. et al. PLoS Pathog. 7, e1002009 (2011).

    CAS  Article  Google Scholar 

  10. Perez-Caballero, D., Hatziioannou, T., Zhang, F., Cowan, S. & Bieniasz, P. D. J. Virol. 79, 15567–15572 (2005).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christopher Aiken.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Aiken, C., Joyce, S. TRIM5 does double duty. Nature 472, 305–306 (2011). https://doi.org/10.1038/472305a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/472305a

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing