TRIM5 proteins limit retroviral infection by targeting the viral coat. It now seems that these proteins can also serve as pattern-recognition receptors, which initiate cellular innate immune responses. See Letter p.361
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Aiken, C., Joyce, S. TRIM5 does double duty. Nature 472, 305–306 (2011). https://doi.org/10.1038/472305a
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DOI: https://doi.org/10.1038/472305a
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