Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Reproductive biology

Progesterone's gateway into sperm

The hormone progesterone rapidly activates intracellular signalling in human sperm, regulating key aspects of their physiology. An ion channel unique to the sperm tail seems to relay progesterone's signal. See Letters p.382 & p.387 See Clarification  p.598

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: CatSper and calcium-ion influx.


  1. Strünker, T. et al. Nature 471, 382–386 (2011).

    Article  ADS  Google Scholar 

  2. Lishko, P. V., Botchkina, I. L. & Kirichok, Y. Nature 471, 387–391 (2011).

    CAS  Article  ADS  Google Scholar 

  3. Blackmore, P. F., Beebe, S. J., Danforth, D. R. & Alexander, N. J. Biol. Chem. 265, 1376–1380 (1990).

    CAS  PubMed  Google Scholar 

  4. Darszon, A. et al. Int. Rev. Cytol. 243, 79–172 (2005).

    CAS  Article  Google Scholar 

  5. Publicover, S., Harper, C. V. & Barratt, C. Nature Cell Biol. 9, 235–242 (2007).

    CAS  Article  Google Scholar 

  6. Baldi, E. et al. Mol. Cell Endocrinol. 308, 39–46 (2009).

    CAS  Article  Google Scholar 

  7. Simoncini, T. & Genazzani, A. R. Eur. J. Endocrinol. 148, 281–292 (2003).

    CAS  Article  Google Scholar 

  8. Quill, T. A., Ren, D., Clapham, D. E. & Garbers, D. L. Proc. Natl Acad. Sci. USA 98, 12527–12531 (2001).

    CAS  Article  ADS  Google Scholar 

  9. Ren, D. et al. Nature 413, 603–609 (2001).

    CAS  Article  ADS  Google Scholar 

  10. Garcia, M. A. & Meizel, S. Biol. Reprod. 60, 102–109 (1999).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Steve Publicover or Christopher Barratt.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Publicover, S., Barratt, C. Progesterone's gateway into sperm. Nature 471, 313–314 (2011).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing