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Reproductive biology

Progesterone's gateway into sperm

The hormone progesterone rapidly activates intracellular signalling in human sperm, regulating key aspects of their physiology. An ion channel unique to the sperm tail seems to relay progesterone's signal. See Letters p.382 & p.387 See Clarification  p.598

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Figure 1: CatSper and calcium-ion influx.

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Correspondence to Steve Publicover or Christopher Barratt.

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Publicover, S., Barratt, C. Progesterone's gateway into sperm. Nature 471, 313–314 (2011). https://doi.org/10.1038/471313a

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