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When catastrophe strikes a cell

In 2–3% of cancers, a single genetic event may have led to hundreds of genomic rearrangements confined to just one or a few chromosomes. This finding challenges the conventional view of how mutations accumulate in oncogenesis.

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Figure 1: Chromothripsis.
Figure 2: Severity of damage matters.


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Correspondence to Xavier Estivill.

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Tubio, J., Estivill, X. When catastrophe strikes a cell. Nature 470, 476–477 (2011).

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