Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


A molecular shield from trauma

Why do some people develop post-traumatic stress disorder, but others emerge from a horrific event relatively unscathed? A molecule involved in orchestrating the brain's response to stress may hold the key to this difference. See Article p.492

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: Post-traumatic stress disorder (PTSD).



  1. Ressler, K. J. et al. Nature 470, 492–497 (2011).

    Article  CAS  ADS  Google Scholar 

  2. Thomas, J. L. et al. Arch. Gen. Psychiatry 67, 614–623 (2010).

    Article  Google Scholar 

  3. Galea, S. et al. N. Engl. J. Med. 346, 982–987 (2002).

    Article  Google Scholar 

  4. Roberts, A. L., Gilman, S. E., Breslau, J., Breslau, N. & Koenen, K. C. Psychol. Med. 41, 71–83 (2011).

    Article  CAS  Google Scholar 

  5. Binder, E. B. et al. J. Am. Med. Assoc. 299, 1291–1305 (2008).

    Article  CAS  Google Scholar 

  6. Murgatroyd, C. et al. Nature Neurosci. 12, 1559–1566 (2009).

    Article  CAS  Google Scholar 

  7. Elliott, E., Ezra-Nevo, G., Regev, L., Neufeld-Cohen, A. & Chen, A. Nature Neurosci. 13, 1351–1353 (2010).

    Article  CAS  Google Scholar 

  8. Gilbertson, M. W. et al. Nature Neurosci. 5, 1242–1247 (2002).

    Article  CAS  Google Scholar 

  9. Etkin, A. & Wager, T. D. Am. J. Psychiatry 164, 1476–1488 (2007).

    Article  Google Scholar 

  10. Bisson, J. & Andrew, M. Cochrane Database Syst. Rev. CD003388 (2007).

  11. Ravindran, L. N. & Stein, M. B. Brain Res. 1293, 24–39 (2009).

    Article  CAS  Google Scholar 

  12. Segman, R. H. et al. Mol. Psychiatry 10, 500–513 (2005).

    Article  CAS  Google Scholar 

  13. Xie, P. et al. Neuropsychopharmacology 35, 1684–1692 (2010).

    Article  CAS  Google Scholar 

  14. Stein, M. B., Campbell-Sills, L. & Gelernter, J. Am. J. Med. Genet. B 150, 900–906 (2009).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Murray B. Stein.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Stein, M. A molecular shield from trauma. Nature 470, 468–469 (2011).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing