Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Functional links between proteins

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Functional annotation by computation.


  1. Marcotte, E. M., Pellegrini, M., Thompson, M. J., Yeates, T. O. & Eisenberg, D. Nature 402, 83–86 (1999).

    Article  ADS  CAS  Google Scholar 

  2. Enright, A., Iliopoulos, I., Kyrpides, N. C. & Ouzounis, C. A. Nature 402, 86–90 (1999).

    Article  ADS  CAS  Google Scholar 

  3. Mendelsohn, A. R. & Brent, R. Science 284, 1948–1950 (1999).

    Article  CAS  Google Scholar 

  4. Koonin, E. V., Tatusov, R. L. & Galperin, M. Y. Curr. Opin. Struct. Biol. 3, 355–363 (1998).

    Article  Google Scholar 

  5. Bork, P. & Koonin, E. V. Nature Genet. 18, 313–318 (1998).

    Article  CAS  Google Scholar 

  6. Chervitz, S. A. et al. Nucleic Acids Res. 27, 74–78 (1999).

    Article  CAS  Google Scholar 

  7. Pellegrini, M., Marcotte, E. M., Thompson, M. J., Eisenberg, D. & Yeates, T. O. Proc. Natl Acad. Sci. USA 96, 4285–4288 (1999).

    Article  ADS  CAS  Google Scholar 

  8. Marcotte, E. M. et al. Science 285, 751–753 (1999).

    Article  CAS  Google Scholar 

  9. Eisen, M. B., Spellman, P. T., Brown, P. O. & Botstein, D. Proc. Natl Acad. Sci. USA 95, 14863–14868 (1998).

    Article  ADS  CAS  Google Scholar 

  10. Gaasterland, T. & Ragan, M. J. Microb. Comp. Genomics 3, 305–312 (1998).

    Google Scholar 

  11. Dandekar, T. et al. Trends Biochem. Sci. 23, 324–328 (1998).

    Article  CAS  Google Scholar 

  12. Overbeek, R., Fonstein, M., D'Souza, M., Pusch, G. D. & Maltsev, N. Proc. Natl Acad. Sci. USA 96, 2896–2901 (1999).

    Article  ADS  CAS  Google Scholar 

  13. Mewes, H. W. Nucleic Acids Res. 27, 44–48 (1999).

    Article  CAS  Google Scholar 

  14. Burley, S. K. et al. Nature Genet. 23, 151–157 (1999).

    Article  CAS  Google Scholar 

  15. Sánchez, R. & Šali, A. Proc. Natl Acad. Sci. USA 95, 13597–13602 (1998).

    Article  ADS  Google Scholar 

  16. Brenner, S. E., Barken, D. & Levitt, M. Nucleic Acids Res. 27, 251–253 (1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Andrej Šali.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Šali, A. Functional links between proteins. Nature 402, 23–26 (1999).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing