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Mechanoregulation

Cellular seat belts

Accurate cell division depends on proper attachment of chromosomes to the microtubule-based division apparatus. An impressive in vitro study shows how applied force plays a pivotal part in regulating such attachment. See Letter p.576

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Figure 1: Tension and chromosome-attachment state.

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Shimamoto, Y., Kapoor, T. Cellular seat belts. Nature 468, 518–519 (2010). https://doi.org/10.1038/468518a

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