Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Chemical biology

Synthetic metabolism goes green

An extension of synthetic biology to a medicinal plant involves the transfer of chlorination equipment from bacteria. This exercise adds implements to the enzymatic toolbox for generating natural products. See Letter p.461

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Catharanthus roseus, more commonly known as the Madagascar periwinkle.

PHOTOS HORTICULTURAL/PHOTOSHOT

References

  1. Austin, M. B., O'Maille, P. E. & Noel, J. P. Nature Chem. Biol. 4, 217–222 (2008).

    CAS  Article  Google Scholar 

  2. Runguphan, W., Qu, X. & O'Connor, S. E. Nature 468, 461–464 (2010).

    ADS  CAS  Article  Google Scholar 

  3. Ziegler, J. & Facchini, P. J. Annu. Rev. Plant Biol. 59, 735–769 (2008).

    CAS  Article  Google Scholar 

  4. Deb Roy, A., Grüschow, S., Cairns, N. & Goss, R. J. M. J. Am. Chem. Soc. 132, 12243–12245 (2010).

    Article  Google Scholar 

  5. Ro, D.-K. et al. Nature 440, 940–943 (2006).

    ADS  CAS  Article  Google Scholar 

  6. O'Connor, S. E. & Maresh, J. J. Nat. Prod. Rep. 23, 532–547 (2006).

    CAS  Article  Google Scholar 

  7. Bernhardt, P., McCoy, E. & O'Connor, S. E. Chem. Biol. 14, 888–897 (2007).

    CAS  Article  Google Scholar 

  8. Tawfik, D. S. Nature Chem. Biol. 6, 692–696 (2010).

    Article  Google Scholar 

  9. Ryan, K. S. & Drennan, C. L. Chem. Biol. 16, 351–364 (2009).

    CAS  Article  Google Scholar 

  10. Loris, E. A. et al. Chem. Biol. 14, 979–985 (2007).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Noel, J. Synthetic metabolism goes green. Nature 468, 380–381 (2010). https://doi.org/10.1038/468380a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/468380a

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing