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Drug discovery

Reader's block

Protein factors can regulate gene expression by binding to specifically modified DNA-associated proteins. Small molecules that selectively interfere with such interaction may be of therapeutic value. See Article p.1067 & Letter p.1119

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Figure 1: Targeting the interaction between bromodomains and acetyl-lysine moieties.


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Taverna, S., Cole, P. Reader's block. Nature 468, 1050–1051 (2010).

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