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Structural biology

Proteins in dynamic equilibrium

Protein molecules in solution exist as an equilibrium of different conformations, but the sizes and shifts of these populations cannot be determined from static structures. A report now shows how they can be measured in solution.

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Figure 1: Conformational states of the Hck enzyme in solution.


  1. Chandonia, J.-M. & Brenner, S. E. Science 311, 347–351 (2006).

    Article  ADS  CAS  Google Scholar 

  2. Yang, S., Blachowicz, L., Makowski, L. & Roux, B. Proc. Natl Acad. Sci. USA 107, 15757–15762 (2010).

  3. Henzler-Wildman, K. & Kern, D. Nature 450, 964–972 (2007).

    Article  ADS  CAS  Google Scholar 

  4. Mittermaier, A. K. & Kay, L. E. Trends Biochem. Sci. 34, 601–611 (2009).

    Article  CAS  Google Scholar 

  5. Zhang, Q. et al. Nature 450, 1263–1267 (2007).

    Article  ADS  CAS  Google Scholar 

  6. Markwick, P. R. L. et al. J. Am. Chem. Soc. 131, 16968–16975 (2009).

    Article  CAS  Google Scholar 

  7. Putnam, C. D., Hammel, M., Hura, G. L. & Tainer, J. A. Q. Rev. Biophys. 40, 191–285 (2007).

    Article  CAS  Google Scholar 

  8. Bernadó, P., Mylonas, E., Petoukhov, M. V., Blackledge, M. & Svergun, D. I. J. Am. Chem. Soc. 129, 5656–5664 (2007).

    Article  Google Scholar 

  9. Bertini, I. et al. J. Am. Chem. Soc. 132, 13553–13558 (2010).

    Article  CAS  Google Scholar 

  10. Sicheri, F., Moarefi, I. & Kuriyan, J. Nature 385, 602–609 (1997).

    Article  ADS  CAS  Google Scholar 

  11. Cowan-Jacob, S. W. et al. Structure 13, 861–871 (2005).

    Article  CAS  Google Scholar 

  12. Baldwin, A. J. & Kay, L. E. Nature Chem. Biol. 5, 808–814(2009).

    Article  CAS  Google Scholar 

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Bernadó, P., Blackledge, M. Proteins in dynamic equilibrium. Nature 468, 1046–1048 (2010).

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