Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Structural biology

Proteins in dynamic equilibrium

Nature volume 468, pages 1046–1048 (2010)Cite this article

Subjects

Protein molecules in solution exist as an equilibrium of different conformations, but the sizes and shifts of these populations cannot be determined from static structures. A report now shows how they can be measured in solution.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Conformational states of the Hck enzyme in solution.

References

  1. Chandonia, J.-M. & Brenner, S. E. Science 311, 347–351 (2006).

    Article  ADS  CAS  Google Scholar 

  2. Yang, S., Blachowicz, L., Makowski, L. & Roux, B. Proc. Natl Acad. Sci. USA 107, 15757–15762 (2010).

  3. Henzler-Wildman, K. & Kern, D. Nature 450, 964–972 (2007).

    Article  ADS  CAS  Google Scholar 

  4. Mittermaier, A. K. & Kay, L. E. Trends Biochem. Sci. 34, 601–611 (2009).

    Article  CAS  Google Scholar 

  5. Zhang, Q. et al. Nature 450, 1263–1267 (2007).

    Article  ADS  CAS  Google Scholar 

  6. Markwick, P. R. L. et al. J. Am. Chem. Soc. 131, 16968–16975 (2009).

    Article  CAS  Google Scholar 

  7. Putnam, C. D., Hammel, M., Hura, G. L. & Tainer, J. A. Q. Rev. Biophys. 40, 191–285 (2007).

    Article  CAS  Google Scholar 

  8. Bernadó, P., Mylonas, E., Petoukhov, M. V., Blackledge, M. & Svergun, D. I. J. Am. Chem. Soc. 129, 5656–5664 (2007).

    Article  Google Scholar 

  9. Bertini, I. et al. J. Am. Chem. Soc. 132, 13553–13558 (2010).

    Article  CAS  Google Scholar 

  10. Sicheri, F., Moarefi, I. & Kuriyan, J. Nature 385, 602–609 (1997).

    Article  ADS  CAS  Google Scholar 

  11. Cowan-Jacob, S. W. et al. Structure 13, 861–871 (2005).

    Article  CAS  Google Scholar 

  12. Baldwin, A. J. & Kay, L. E. Nature Chem. Biol. 5, 808–814(2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pau Bernadó is at the Institute for Research in Biomedicine, 08028-Barcelona, Spain. pau.bernado@irbbarcelona.org,

    Pau Bernadó

  2. Martin Blackledge is at the Institute de Biologie Structurale Jean-Pierre Ebel, Commissariat à l'Energie Atomique, CNRS, Université Joseph Fourier, Grenoble 38027, France. martin.blackledge@ibs.fr,

    Martin Blackledge

Authors
  1. Pau Bernadó
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Martin Blackledge
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bernadó, P., Blackledge, M. Proteins in dynamic equilibrium. Nature 468, 1046–1048 (2010). https://doi.org/10.1038/4681046a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/4681046a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing