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Structural biology

Proteins in dynamic equilibrium

Protein molecules in solution exist as an equilibrium of different conformations, but the sizes and shifts of these populations cannot be determined from static structures. A report now shows how they can be measured in solution.

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Figure 1: Conformational states of the Hck enzyme in solution.

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Bernadó, P., Blackledge, M. Proteins in dynamic equilibrium. Nature 468, 1046–1048 (2010). https://doi.org/10.1038/4681046a

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