The protein angiotensinogen must undergo conformational changes to be cleaved into a precursor of the hormone angiotensin, which increases blood pressure. Oxidative stress seems to mediate this structural alteration. See Letter p.108
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Zhou, A. et al. Nature 468, 108–111 (2010).
Sharma, A. M. J. Mol. Med. 76, 568–571 (1998).
Chobanian, A. V. et al. Hypertension 42, 1206–1252 (2003).
Rajagopalan, S. et al. J. Clin. Invest. 97, 1916–1923 (1996).
Nguyen, G. et al. J. Clin. Invest. 109, 1417–1427 (2002).
Jeunemaitre, X. et al. Cell 71, 169–180 (1992).
Ward, K. et al. Nature Genet. 4, 59–61 (1993).
Morgan, T., Craven, C., Nelson, L., Lalouel, J. M. & Ward, K. J. Clin. Invest. 100, 1406–1415 (1997).
Inoue, I. et al. J. Clin. Invest. 99, 1786–1797 (1997).
Grobe, J. L. et al. Hypertension 56, 981–987 (2010).
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Sigmund, C. On stress and pressure. Nature 468, 46–47 (2010). https://doi.org/10.1038/468046a
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