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Slicer for DNA

Many bacteria and archaea protect themselves from viruses and other invasive genomes through a genetic interference pathway. The small RNAs that guide this defence specify the direct cleavage of foreign DNA. See Article p.67

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Figure 1: RNA-guided DNA cleavage by the core CRISPR machinery.


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Sontheimer, E., Marraffini, L. Slicer for DNA. Nature 468, 45–46 (2010).

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