Proteins that pump a wide range of toxic compounds out of cells are ubiquitous in nature, but crystal structures for one family of these transporters have remained elusive. Until now. See Letter p.991
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Engineered MATE multidrug transporters reveal two functionally distinct ion-coupling pathways in NorM from Vibrio cholerae
Communications Biology Open Access 11 May 2021
-
Structural basis for the blockade of MATE multidrug efflux pumps
Nature Communications Open Access 06 August 2015
-
Microbes in the neonatal intensive care unit resemble those found in the gut of premature infants
Microbiome Open Access 28 January 2014
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
He, X. et al. Nature 467, 991–994 (2010).
Omote, H., Hiasa, M., Matsumoto, T., Otsuka, M. & Moriyama, Y. Trends Pharmacol. Sci. 27, 587–593 (2006).
Brown, M. H., Paulsen, I. T. & Skurray, R. A. Mol. Microbiol. 31, 394–395 (1999).
Saier, M. H. Jr & Paulsen, I. T. Semin. Cell Dev. Biol. 12, 205–213 (2001).
Yamashita, A., Singh, S. K., Kawate, T., Jin, Y. & Gouaux, E. Nature 437, 215–223 (2005).
Shimamura, T. et al. Science 328, 470–473 (2010).
Khare, D., Oldham, M. L., Orelle, C., Davidson, A. L. & Chen, J. Mol. Cell 33, 528–536 (2009).
Gutmann, D. A. P., Ward, A., Urbatsch, I. L., Chang, G. & van Veen, H. W. Trends Biochem. Sci. 35, 36–42 (2010).
Morita, Y., Kataoka, A., Shiota, S., Mizushima, T. & Tsuchiya, T. J. Bacteriol. 182, 6694–6697 (2000).
Yerushalmi, H. & Schuldiner, S. Biochemistry 39, 14711–14719 (2000).
Sigal, N., Fluman, N., Siemion, S. & Bibi, E. J. Biol. Chem. 284, 6966–6971 (2009).
Schaedler, T. A. & van Veen, H. W. FASEB J. 24, 3653–3661 (2010).
Padan, E. Trends Biochem. Sci. 33, 435–443 (2008).
Schumacher, M. A. et al. Science 294, 2158–2163 (2001).
Murakami, S., Nakashima, R., Yamashita, E., Matsumoto, T. & Yamaguchi, A. Nature 443, 173–179 (2006).
Aller, S. G. et al. Science 323, 1718–1722 (2009).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
van Veen, H. Last of the multidrug transporters. Nature 467, 926–927 (2010). https://doi.org/10.1038/467926a
Published:
Issue Date:
DOI: https://doi.org/10.1038/467926a
This article is cited by
-
Engineered MATE multidrug transporters reveal two functionally distinct ion-coupling pathways in NorM from Vibrio cholerae
Communications Biology (2021)
-
Structural basis for the blockade of MATE multidrug efflux pumps
Nature Communications (2015)
-
Microbes in the neonatal intensive care unit resemble those found in the gut of premature infants
Microbiome (2014)
-
Ribosome-targeting antibiotics and mechanisms of bacterial resistance
Nature Reviews Microbiology (2014)