A female can develop a diabetes-like disease due to a high fat content in her father's diet before she was conceived. Epigenetic modifications of the father's sperm DNA might underlie this peculiar observation. See Letter p.963
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References
Ng, S.-F. et al. Nature 467, 963–966 (2010).
Skinner, M. K., Manikkam, M. & Guerrero-Bosagna, C. Trends Endocrinol. Metab. 21, 214–222 (2010).
Barton, T. S., Robaire, B. & Hales, B. F. Toxicol. Sci. 100, 495–503 (2007).
Aitken, R. J., Koopman, P. & Lewis, S. E. M. Nature 432, 48–52 (2004).
Sharpe, R. M. Phil. Trans. R. Soc. B 365, 1697–1712 (2010).
Du Plessis, S. S., Cabler, S., McAlister, D. A., Sabanegh, E. & Agarwal, A. Nature Rev. Urol. 7, 153–161 (2010).
Guerrero-Bosagna, C., Settles, M., Lucker, B. & Skinner, M. K. PLoS ONE 5, e13100 (2010).
Puri, D., Dhawan, J. & Mishra, R. K. Epigenetics doi:10.4161/epi.5.5.12005 (2010).
Jirtle, R. L. & Skinner, M. K. Nature Rev. Genet. 8, 253–262 (2007).
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Skinner, M. Fathers' nutritional legacy. Nature 467, 922–923 (2010). https://doi.org/10.1038/467922a
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DOI: https://doi.org/10.1038/467922a
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