The T-cell receptor on the surface of T cells requires antigen recognition to function. Structural studies reveal that its predecessor, the pre-T-cell receptor, is much more independent. See Letter p.844
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Malissen, B., Luche, H. Egocentric pre–T–cell receptors. Nature 467, 793–794 (2010). https://doi.org/10.1038/467793a
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DOI: https://doi.org/10.1038/467793a
