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DNA repair

A protein giant in its entirety

Purification of the human tumour-suppressor protein BRCA2, which is crucial for DNA repair, has been a formidable challenge owing to its large size. That mission is now accomplished, providing biochemical insight. See Article p.678

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Figure 1: The multifaceted role of BRCA2 in homologous recombination.

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Zou, L. A protein giant in its entirety. Nature 467, 667–668 (2010). https://doi.org/10.1038/467667a

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