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Gene expression

The coherent Mediator

Enhancer sequences increase gene transcription with the help of a co-activator complex, the Mediator. Another protein complex — cohesin — seems to work with Mediator to bring together enhancers and promoters. See Article p. 430

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Figure 1: The Mediator–cohesin complex.


  1. Taatjes, D. Trends Biochem. Sci. 35, 315–322 (2010).

    CAS  Article  Google Scholar 

  2. Kagey, M. H. et al. Nature 467, 430–435 (2010).

    ADS  CAS  Article  Google Scholar 

  3. Max, T., Sogaard, M. & Svejstrup, J. Q. J. Biol. Chem. 282, 14113–14120 (2009).

    Article  Google Scholar 

  4. Wood, A. J., Severson, A. F. & Meyer, B. J. Nature Rev. Genet. 11, 391–404 (2010).

    CAS  Article  Google Scholar 

  5. Carretero, M., Remeseiro, S. & Losada, A. Curr. Opin. Cell Biol. 22, 1–7 (2010).

    Article  Google Scholar 

  6. Dorsett, D. Chromosome Res. 17, 185–200 (2009).

    CAS  Article  Google Scholar 

  7. Schmidt, D. et al. Genome Res. 20, 578–588 (2010).

    CAS  Article  Google Scholar 

  8. Philibert, R. A. & Madan, A. Pharmacogenomics 8, 909–916 (2007).

    CAS  Article  Google Scholar 

  9. Liu, J. et al. PLoS Biol. 7, e1000119 (2009).

    Article  Google Scholar 

  10. Schoenfelder, S., Clay, I. & Fraser, P. Curr. Opin. Genet. Dev. 20, 127–133 (2010).

    CAS  Article  Google Scholar 

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Ohlsson, R. The coherent Mediator. Nature 467, 406–407 (2010).

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