Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Gene expression

The coherent Mediator

Enhancer sequences increase gene transcription with the help of a co-activator complex, the Mediator. Another protein complex — cohesin — seems to work with Mediator to bring together enhancers and promoters. See Article p. 430

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: The Mediator–cohesin complex.

References

  1. Taatjes, D. Trends Biochem. Sci. 35, 315–322 (2010).

    CAS  Article  Google Scholar 

  2. Kagey, M. H. et al. Nature 467, 430–435 (2010).

    ADS  CAS  Article  Google Scholar 

  3. Max, T., Sogaard, M. & Svejstrup, J. Q. J. Biol. Chem. 282, 14113–14120 (2009).

    Article  Google Scholar 

  4. Wood, A. J., Severson, A. F. & Meyer, B. J. Nature Rev. Genet. 11, 391–404 (2010).

    CAS  Article  Google Scholar 

  5. Carretero, M., Remeseiro, S. & Losada, A. Curr. Opin. Cell Biol. 22, 1–7 (2010).

    Article  Google Scholar 

  6. Dorsett, D. Chromosome Res. 17, 185–200 (2009).

    CAS  Article  Google Scholar 

  7. Schmidt, D. et al. Genome Res. 20, 578–588 (2010).

    CAS  Article  Google Scholar 

  8. Philibert, R. A. & Madan, A. Pharmacogenomics 8, 909–916 (2007).

    CAS  Article  Google Scholar 

  9. Liu, J. et al. PLoS Biol. 7, e1000119 (2009).

    Article  Google Scholar 

  10. Schoenfelder, S., Clay, I. & Fraser, P. Curr. Opin. Genet. Dev. 20, 127–133 (2010).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ohlsson, R. The coherent Mediator. Nature 467, 406–407 (2010). https://doi.org/10.1038/467406a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/467406a

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing