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Drug development

Longer-lived proteins

Short residence times in the bloodstream reduce the effectiveness of protein drugs. Application of an approach that combines protein and polymer engineering prolongs circulation time and increases drug uptake by tumours.

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Figure 1: Drug modification with a feather boa.

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Hubbell, J. Longer-lived proteins. Nature 467, 1051–1052 (2010). https://doi.org/10.1038/4671051a

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