Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Physiology: The bones of contention

The skeleton may provide more than just structural support. Alla Katsnelson investigates the rise of bone as a metabolic regulator.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout


  1. Fulzele, K. et al. Cell 142, 309-319 (2010).

    Article  CAS  Google Scholar 

  2. Ducy, P. et al. Cell 100, 197-207 (2000).

    Article  CAS  Google Scholar 

  3. Yadav, V. K. et al. Cell 138, 976-989 (2009).

    Article  CAS  Google Scholar 

  4. Lee, N. K. et al. Cell 130, 456-469 (2007).

    Article  CAS  Google Scholar 

  5. Ferron, M. et al. Cell 142, 296-308 (2010).

    Article  CAS  Google Scholar 

  6. Strapazzon, G., De Toni, L. & Foresta, C. Osteoporos. Int. doi:10.1007/s00198-010-1322-2 (2010).

Download references

Author information

Authors and Affiliations


Related links

Related links

Related external links

Gerard Karsenty's website

Thomas Clemens's website

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Katsnelson, A. Physiology: The bones of contention. Nature 466, 914–915 (2010).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing