Antidiabetic drugs that activate the protein PPARγ had a bright start but soon lost their appeal because of undesirable side effects. Subtle modifications may once again make them suitable for treating diabetes.
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Houtkooper, R., Auwerx, J. New life for antidiabetic drugs. Nature 466, 443–444 (2010). https://doi.org/10.1038/466443a
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DOI: https://doi.org/10.1038/466443a
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