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New life for antidiabetic drugs

Antidiabetic drugs that activate the protein PPARγ had a bright start but soon lost their appeal because of undesirable side effects. Subtle modifications may once again make them suitable for treating diabetes.

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Figure 1: Regulation of PPARγ activity.


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Houtkooper, R., Auwerx, J. New life for antidiabetic drugs. Nature 466, 443–444 (2010).

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