Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Protein synthesis

Translocation in slow motion

Time-resolved electron microscopy can capture structural changes in active macromolecular complexes, but detailed imaging is essential. The dynamics of one step in protein synthesis has been deduced from two million images.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Movement back and forth along the ribosome.


  1. Fischer, N., Konevega, A. L., Wintermeyer, W., Rodnina, M. V. & Stark, H. Nature 466, 329–333 (2010).

    ADS  CAS  Article  Google Scholar 

  2. Schmeing, T. M. & Ramakrishnan, V. Nature 461, 1234–1242 (2009).

    ADS  CAS  Article  Google Scholar 

  3. Schmeing, T. M., Huang, K. S., Kitchen, D. E., Strobel, S. A. & Steitz, T. A. Mol. Cell 20, 437–448 (2005).

    CAS  Article  Google Scholar 

  4. Trobro, S. & Åqvist, J. Proc. Natl Acad. Sci. USA 102, 12395–12400 (2005).

    ADS  CAS  Article  Google Scholar 

  5. Ogle, J. M. & Ramakrishnan, V. Annu. Rev. Biochem. 74, 129–177 (2005).

    CAS  Article  Google Scholar 

  6. Weixlbaumer, A. et al. Science 322, 953–956 (2008).

    ADS  CAS  Article  Google Scholar 

  7. Laurberg, M. et al. Nature 454, 852–857 (2008).

    ADS  CAS  Article  Google Scholar 

  8. Sund, J., Andér, M. & Åqvist, J. Nature 465, 947–950 (2010).

    ADS  CAS  Article  Google Scholar 

  9. Valle, M. et al. Cell 114, 123–134 (2003).

    CAS  Article  Google Scholar 

  10. Moazed, D. & Noller, H. J. Nature 342, 142–148 (1989).

    ADS  CAS  Article  Google Scholar 

  11. Rodnina, M. V. et al. Nature 385, 37–41 (1997).

    ADS  CAS  Article  Google Scholar 

  12. Kamerlin, S. C. L. & Warshel, A. Proteins 78, 1339–1375 (2010).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ehrenberg, M. Translocation in slow motion. Nature 466, 325–326 (2010).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing