Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Neuroscience

MicroRNA knocks down cocaine

Cocaine abuse results in increased craving for the drug. But in the long run, cocaine intake induces the expression of a microRNA in the brain, and this seems to limit further drug intake.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Counteracting cocaine intake.

References

  1. Hollander, J. A. et al. Nature 466, 197–202 (2010).

    ADS  CAS  Article  Google Scholar 

  2. Nestler, E. J. Neuropharmacology 47 (suppl.), 24–32 (2004).

    CAS  Article  Google Scholar 

  3. Turrigiano, G. G. Trends Neurosci. 22, 221–227 (1999).

    CAS  Article  Google Scholar 

  4. Lee, R. C., Feinbaum, R. L. & Ambros, V. Cell 75, 843–854 (1993).

    CAS  Article  Google Scholar 

  5. Reinhart, B. J. et al. Nature 403, 901–906 (2000).

    ADS  CAS  Article  Google Scholar 

  6. Bentwich, I. et al. Nature Genet. 37, 766–770 (2005).

    CAS  Article  Google Scholar 

  7. Carlezon, W. A. et al. Science 282, 2272–2275 (1998).

    ADS  CAS  Article  Google Scholar 

  8. Dong, Y. et al. Nature Neurosci. 9, 475–477 (2006).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Picciotto, M. MicroRNA knocks down cocaine. Nature 466, 194–195 (2010). https://doi.org/10.1038/466194a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/466194a

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing