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Autophagy

Snapshot of the network

Nature volume 466, pages 38–39 (2010)Cite this article

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Autophagy is an essential cellular process for protein and organelle quality control. Analyses of proteins that interact with the human autophagic machinery provide an outline of the molecular organization of this pathway.

To survive, cells must get rid of damaged, obsolete or dangerous components. They do so by the process of autophagy, which involves a series of dynamic membrane-rearrangement reactions mediated by a core set of proteins — the Atg proteins1. Up to now, these proteins have largely been analysed in the context of discrete macromolecular complexes that function at specific steps in the autophagy pathway. In this issue, Behrends et al.2 (page 68) report a tour de force of proteomic analysis that has identified human proteins that interact with the core autophagic machinery and related molecules.

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Authors and Affiliations

  1. Beth Levine is in the Departments of Internal Medicine and Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. beth.levine@utsouthwestern.edu,

    Beth Levine

  2. Rama Ranganathan is in the Green Center for Systems Biology and the Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. rama.ranganathan@utsouthwestern.edu,

    Rama Ranganathan

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  1. Beth Levine
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  2. Rama Ranganathan
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Levine, B., Ranganathan, R. Snapshot of the network. Nature 466, 38–39 (2010). https://doi.org/10.1038/466038a

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