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Blood-vessel formation

Bridges that guide and unite

To form new blood vessels, the endothelial tip cells of two existing vessels come together by the process of anastomosis. But how do they find each other? Macrophages seem to provide a bridge and mediate their union.

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Figure 1: Bridging branch formation.


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Schmidt, T., Carmeliet, P. Bridges that guide and unite. Nature 465, 697–699 (2010).

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