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Q&A: Cancer

Clues from cell metabolism

Interest in the abnormal metabolism exhibited by cancer cells has been reawakened by the discovery of oncogenic mutations in metabolic enzymes, and by tools that monitor metabolism in living cells. Existing and emerging therapies aim to target this abnormal metabolism in various ways.

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Figure 1: Biochemistry of cancer-cell metabolism.
Figure 2: Regulation of HIF function.

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W.G.K. is a consultant to FibroGen Pharmaceuticals and to Agios Pharmaceuticals. C.B.T. is a founder and chair of the advisory board of Agios Pharmaceuticals.

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Kaelin, W., Thompson, C. Clues from cell metabolism. Nature 465, 562–564 (2010). https://doi.org/10.1038/465562a

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