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DNA repair

How to accurately bypass damage

Ultraviolet radiation can cause cancer through DNA damage — specifically, by linking adjacent thymine bases. Crystal structures show how the enzyme DNA polymerase η accurately bypasses such lesions, offering protection.

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Figure 1: Accurate lesion bypass by Polη.


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Broyde, S., Patel, D. How to accurately bypass damage. Nature 465, 1023–1024 (2010).

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