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A plastic axonal hotspot

Neurons generate their output signal — the action potential — in a distinct region of the axon called the initial segment. The location and extent of this trigger zone can be modified by neural activity to control excitability.

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Figure 1: Intrinsic plasticity, courtesy of the axon initial segment (AIS).


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Gründemann, J., Häusser, M. A plastic axonal hotspot. Nature 465, 1022–1023 (2010).

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