Amide bonds connect the amino acids in proteins and occur in many other useful molecules. An amide-forming reaction that turns the conventional approach on its head offers a practical way of making these bonds.
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References
Shen, B., Makley, D. M. & Johnston, J. N. Nature 465, 1027–1032 (2010).
Williamson, J. R. Cell 139, 1041–1043 (2009).
Yonath, A. Angew. Chem. Int. Edn 49, 4340–4354 (2010).
Montalbetti, C. A. G. N. & Falque, V. Tetrahedron 61, 10827–10852 (2005).
Sheehan, J. C. & Hess, G. P. J. Am. Chem. Soc. 77, 1067–1068 (1955).
Merrifield, R. B. Angew. Chem. Int. Edn Engl. 24, 799–810 (1985).
Köhn, M. & Breinbauer, R. Angew. Chem. Int. Edn 43, 3106–3116 (2004).
Kent, S. B. H. Chem. Soc. Rev. 38, 338–351 (2009).
Gunanathan, C., Ben-David, Y. & Milstein, D. Science 317, 790–792 (2007).
Valeur, E. & Bradley, M. Chem. Soc. Rev. 38, 606–631 (2009).
Seebach, D. Angew. Chem. Int. Edn Engl. 18, 239–258 (1979).
Singh, A., Yoder, R. A., Shen, B. & Johnston, J. N. J. Am. Chem. Soc. 129, 3466–3467 (2007).
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Scheidt, K. Amide bonds made in reverse. Nature 465, 1020–1022 (2010). https://doi.org/10.1038/4651020a
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DOI: https://doi.org/10.1038/4651020a