Diverse messenger RNAs, and thus proteins, can be generated from a single piece of DNA. A computational approach is helping to uncover complex combinatorial rules by which specific gene instructions are selected.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Barash, Y. et al. Nature 465, 53–59 (2010).
Nirenberg, M. Trends Biochem. Sci. 29, 46–54 (2004).
Nilsen, T. W. & Graveley, B. R. Nature 463, 457–463 (2010).
Chasin, L. A. Adv. Exp. Med. Biol. 623, 85–106 (2007).
Chen, M. & Manley, J. L. Nature Rev. Mol. Cell Biol. 10, 741–754 (2009).
Blencowe, B. J., Ahmad, S. & Lee, L. J. Genes Dev. 23, 1379–1386 (2009).
Luco, R. F. et al. Science 327, 996–1000 (2010).
Fox-Walsh, K. & Fu, X.-D. Dev. Cell 18, 336–338 (2010).
Piqué, M., López, J. M., Foissac, S., Guigó, R. & Méndez, R. Cell 132, 434–448 (2008).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tejedor, J., Valcárcel, J. Breaking the second genetic code. Nature 465, 45–46 (2010). https://doi.org/10.1038/465045a
Published:
Issue Date:
DOI: https://doi.org/10.1038/465045a
This article is cited by
-
Alternative splicing: a pivotal step between eukaryotic transcription and translation
Nature Reviews Molecular Cell Biology (2013)
