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Cell biology forum

Genome-wide view of mitosis

An exceptionally large-scale project aimed at assigning function to all protein-coding genes in the human genome is reported on page 721 by Neumann et al.1. Here are two complementary views on the experimental design and analysis, and on how useful the findings will be to cell biologists.

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Figure 1: Note the difference.

A, JUTTA BULKESCHER (EMBL); B, MAYUMI ISOKANE (EMBL)

References

  1. Neumann, B. et al. Nature 464, 721–727 (2010).

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  2. http://www.mitocheck.org

  3. Poser, I. et al. Nature Meth. 5, 409–415 (2008).

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  4. Bramsen, J. B. et al. Nucleic Acids Res. 37, 2867–2881 (2009).

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  5. HÜbner, N. C. et al. Chromosoma 119, 149–165 (2010).

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  6. Lamb, J. et al. Science 313, 1929–1935 (2006).

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Swedlow, J., Cotta-Ramusino, C. & Elledge, S. Genome-wide view of mitosis. Nature 464, 684–685 (2010). https://doi.org/10.1038/464684a

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