Development

Ubiquitin tag for sperm mitochondria

Abstract

Like other mammals, humans inherit mitochondria from the mother only, even though the sperm contributes nearly one hundred mitochondria to the fertilized egg. In support of the idea that this strictly maternal inheritance of mitochondrial DNA arises from the selective destruction of sperm mitochondria1,2, we show here that sperm mitochondria inside fertilized cow and monkey eggs are tagged by the recycling marker protein ubiquitin3. This imprint is a death sentence that is written during spermatogenesis and executed after the sperm mitochondria encounter the egg's cytoplasmic destruction machinery.

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Figure 1: Ubiquitination of sperm mitochondria in mammalian zygotes and embryos.

References

  1. 1

    Hutchinson, C. A., Newbold, J. E. & Potter, S. S. Nature 251, 536–538 (1974).

    Article  ADS  Google Scholar 

  2. 2

    Giles, R. E., Blanc, H., Cann, H. M. & Wallace, D. C. Proc. Natl Acad. Sci. USA 77 6715–6719 (1980).

    CAS  Article  ADS  Google Scholar 

  3. 3

    Ciechanover, A. Cell 79, 13–21 (1994).

    CAS  Article  Google Scholar 

  4. 4

    Perreault, S. D., Wolf, R. A. & Zirkin, B. R. Dev. Biol. 101, 160–167 (1984).

    CAS  Article  Google Scholar 

  5. 5

    Szöllösi, D. J. Exp. Zool. 159, 367–378 (1965).

    Article  Google Scholar 

  6. 6

    Sutovsky, P., Navara, C. S. & Schatten, G. Biol. Reprod. 55, 1195–1205 (1996).

    CAS  Article  Google Scholar 

  7. 7

    Cummins, J. M., Wakayama, T. & Yanagimachi, R. Zygote 5, 301–308 (1997).

    CAS  Article  Google Scholar 

  8. 8

    Gyllensten, U., Wharton, D., Josefsson, A. & Wilson, A. C. Nature 352 255–257 (1991).

    CAS  Article  ADS  Google Scholar 

  9. 9

    Kaneda, H. et al. Proc. Natl Acad. Sci. USA 92, 4542–4546 (1995).

    CAS  Article  ADS  Google Scholar 

  10. 10

    Fisk, H. A. & Yaffe, M. P. J. Cell Biol. 145, 1199–1208 (1999).

    CAS  Article  Google Scholar 

  11. 11

    Choongkittaworn, N. M., Kim, K. H., Danner, D. B. & Griswold, M. D. Biol. Reprod. 49, 300–310 (1993).

    CAS  Article  Google Scholar 

  12. 12

    Kato, Y. et al. Science 282, 2095–2098 (1998).

    CAS  Article  ADS  Google Scholar 

  13. 13

    Renard, J. P. et al. Lancet 353, 1489–1491 (1999).

    CAS  Article  Google Scholar 

  14. 14

    Barrit, J. et al. Fertil. Steril. 72, 31–32 (1999).

    Google Scholar 

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Correspondence to Gerald Schatten.

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Sutovsky, P., Moreno, R., Ramalho-Santos, J. et al. Ubiquitin tag for sperm mitochondria. Nature 402, 371–372 (1999). https://doi.org/10.1038/46466

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